United States securities and exchange commission logo August 2, 2021 Tillman U. Gerngross, Ph.D. Chief Executive Officer Adagio Therapeutics, Inc. 303 Wyman Street, Suite 300 Waltham, MA 02451 Re: Adagio Therapeutics, Inc. Amendment No. 1 to Registration Statement on Form S-1 Filed August 2, 2021 File No. 333-257975 Dear Dr. Gerngross: We have reviewed your amended registration statement and have the following comment. Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe our comment applies to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing any amendment to your registration statement and the information you provide in response to this comment, we may have additional comments. Amendment No. 1 to Registration Statement on Form S-1 filed August 2, 2021 Business License Agreement with Biocon Biologics Limited, page 145 1. Please expand your disclosure regarding the license agreement with Biocon to describe the material terms of the agreement, including payment terms and termination provisions. Please also file the agreement as an exhibit to the registration statement, or advise. See Item 601(b)(10) of Regulation S-K. Tillman U. Gerngross, Ph.D. Adagio Therapeutics, Inc. August 2, 2021 Page 2 You may contact Tara Harkins at 202-551-3639 or Al Pavot at 202-551-3738 if you have questions regarding comments on the financial statements and related matters. Please contact Abby Adams at 202-551-6902 or Irene Paik at 202-551-6553 with any other questions. Sincerely, FirstName LastNameTillman U. Gerngross, Ph.D. Division of Corporation Finance Comapany NameAdagio Therapeutics, Inc. Office of Life Sciences August 2, 2021 Page 2 cc: Divakar Gupta, Esq. FirstName LastName